(urate: oxygen oxidoreductase; EC 18.104.22.168)
Uricase or Urate oxidase catalyzes the following reaction in
all mammals except the primates and a few other species.
Uric Acid + 2H2O +O2 ------> Allantoin + H2O2 + CO2
The enzyme is widely distributed in the tissues of lower
mammals and in some microorganisms. Uricase is extensively
used for the determination of uric acid in biological
fluids. (Domagk, G.F. and Schlicke, H.H., Anal. Biochem., 22,